Chemical Metabolomics – Development of New Tools for Advanced Microbiome Analysis and Biomarker Discovery
The Globisch lab is an international research group with focus on the development of new Chemical Biology-based methodologies to improve the analysis of small molecule metabolites in biological samples. These new methodologies are aimed at enhancing the scope of metabolomics-based research. In our multidisciplinary research, we work at the interface of Chemistry and Biology with a combination of Organic Chemistry, Chemical Biology techniques, Biochemistry, mass spectrometric analysis of metabolites, and metabolomics. The discovery of specific early-stage biomarkers, new drug targets and the development of new therapeutic interventions are crucial for disease prevention and management towards personalized medicine.
Biomarker Discovery is a challenging and multidisciplinary task. We develop new tools for mass spectrometric analysis and are focused on elucidating microbiota metabolism. We investigate any human sample type, e.g., fecal, urine, and plasma samples from pancreatic cancer patients.
Selected publications
W. Lin, L. Gerullat, P.R. Braadland, A. Fournier, J.R. Hov, D. Globisch
Angew. Chem. Int. Ed. 2024, 63, e202318579. Inside Cover
“Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4-Nitrophenyl-2H-azirine“
L. Cheng+, M.S.P. Correia+, S.M. Higdon, F. Romero Garcia, I. Tsiara, E. Joffré, Å. Sjöling, F. Boulund, E.J. Norin, L. Engstrand, D. Globisch*, J. Du*
Gut Microbes 2024, 16, 2356275.
“The protective role of commensal gut microbes and their metabolites against bacterial pathogens“
A. Kaur, W. Lin, V. Dovhalyuk, L. Driutti, M.L. Di Martino, M. Vujasinovic, J.-M. Löhr, M. Sellin, D. Globisch
Chem. Sci. 2023, 14, 5291-5301. Cover Image
“Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites”
W. Lin, L. P. Conway, M. Vujasinovic, J.-M. Löhr, D. Globisch
Angew. Chem. Int. Ed. 2021, 60, 23232–23240.
“Chemoselective and highly sensitive quantification of gut microbiome and human metabolites”
L. P. Conway+, V. Rendo+, M. S. P. Correia, I. A. Bergdahl, T. Sjöblom*, D. Globisch*
Angew. Chem. Int. Ed. 2020, 59, 14342–14346.
“Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2”
N. Garg+, L. P. Conway+, C. Ballet, M. S. P. Correia, F. K. S. Olsson, M. Vujasinovic, J.-M. Löhr, D. Globisch
Angew. Chem. Int. Ed. 2018, 57, 13805–13809.
“Chemoselective Probe Harboring a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism”
C. Ballet+, M.S.P. Correia+, L.P. Conway, T.L. Locher, L.C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.M. Löhr, D. Globisch
Chem. Sci. 2018, 9, 6233–6239. HOT paper
“New selective and mass spectrometric methodology for the investigation of gut microbiota-derived metabolites”
D. Globisch, A.Y. Moreno, M.S. Hixon, A.A.K. Nunes, J.R. Denery, S. Specht, A. Hoerauf, K.D. Janda
Proc. Natl. Acad. Sci. U S A. 2013, 110, 4218–4223. Cover Image
“Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness”
D. Globisch, C.A. Lowery, K.C. McCague, K.D. Janda
Angew. Chem. Int. Ed. 2012, 51, 4204–4208. Inside Cover
“Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species”
D. Globisch, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A.C. Kneuttinger, M. Müller, S.A. Sieber, T. Carell
Angew. Chem. Int. Ed. 2011, 50, 9739–9742. Hot Paper
“Systems-Based Analysis of Modified tRNA Bases”