Uppsala University, Uppsala, Sweden 
57) L.E. McCoubrey, C. Shen, S. Mwasambu, A. Favaron, N. Sangfuang, S. Thomaidou, M. Orlu, D. Globisch, A.W. Basit Eur. J. Pharm. Sci. 2024, 203, 106922.
“Characterising and preventing the gut microbiota’s inactivation of trifluridine, a colorectal cancer drug“
56) X. Zhang, N. Rameika, L. Zhong, V. Rendo, M. Veanes, S. Kundu, S. Nuciforo, J. Dupuis, M.A. Azhar, I. Tsiara, P. Seeburger, S. Al Nassralla, V. Ljungström, R. Svensson, I. Stoimenov, P. Artursson, M.H. Heim, D. Globisch, T. Sjöblom eBioMedicine 2024, 109, 105368.
“Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib“
55) L. Cheng+, M.S.P. Correia+, S.M. Higdon, F. Romero Garcia, I. Tsiara, E. Joffré, Å. Sjöling, F. Boulund, E.J. Norin, L. Engstrand, D. Globisch*, J. Du*
Gut Microbes 2024, 16, 2356275.
“The protective role of commensal gut microbes and their metabolites against bacterial pathogens“
54) T. Vallianatou, C. de Souza Anselmo, I. Tsiara, N.B. Béchet, I. Lundgaard, D. Globisch
ACS Chem. Neurosc. 2024, 15, 1335–1341.
Cover Art
“Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain“
Highlighted in a Bright Giant blog.
53) W. Lin, L. Gerullat, P.R. Braadland, A. Fournier, J.R. Hov, D. Globisch
Angew. Chem. Int. Ed. 2024, 63, e202318579.
Cover Art
“Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4-Nitrophenyl-2H-azirine“
52) I. Tsiara, A. Riemer, M.S.P. Correia, A. Rodriguez-Mateos, D. Globisch
Anal. Chem. 2023, 95, 12565–12571.
“Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes“
51) W. Lin, K. Mellinghaus, A. Rodriguez-Mateos, D. Globisch
Food Chem. 2023, 425, 136481.
“Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics“
50) W. Lin, F. Romero García, E.L. Norin, D. Kart, L. Engstrand, J. Du, D. Globisch
Chem. Comm. 2023, 59, 5843-5846. (Part of the 2023 Pioneering Investigators Series)
Cover Art
“Sensitive Quantification of Short-Chain Fatty Acids Combined with Global Metabolomics in Microbiome Cultures“
49) A. Kaur, W. Lin, V. Dovhalyuk, L. Driutti, M.L. Di Martino, M. Vujasinovic, J.-M. Löhr, M. Sellin, D. Globisch
Chem. Sci. 2023, 14, 5291-5301.
Cover Art
“Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites“
47) N. Nyström, S. Prast-Nielsen, M.S.P. Correia, D. Globisch, L. Engstrand, I. Schuppe Koistinen, J. Halfvarson
J Crohns Colitis 2023, 17, 418-432.
“Mucosal and plasma metabolomes in new-onset paediatric inflammatory bowel disease: correlations with disease characteristics and plasma inflammation protein markers“
48) H. Bi, J. Tranell, D.C. Harper, W. Lin, J. Li, A.R. Hellström, M. Larsson, C.J. Rubin, C. Wang, S. Sayyab, S. Kerje, B. Bed’hom, D. Gourichon, S. Ito, K. Wakamatsu, M. Tixier-Boichard, M.S. Marks, D. Globisch, L. Andersson
PLoS Genet. 2023, 19(4) e1010724.
“A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken“
46) M.S.P. Correia, B. Thapa, M. Vujasinovic, J.-M. Löhr, D. Globisch
RSC Adv. 2021, 11, 34788-34794. Featured in the Emerging Investigators Series.
“Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency“
45) Y. Fareed, D. Braun, M. Flasch, D. Globisch, B. Warth
Exposome 2022, 2, osac008.
“A broad, exposome-type evaluation of xenobiotic phase II biotransformation in human biofluids by LC-MS/MS“
44) X. Zhang, E. Akcan, M.S.P. Correia, N. Rameika, S. Kundu, I. Stoimenov, V. Rendo, A.U. Eriksson, M. Haraldsson, D. Globisch, T. Sjöblom
Biochem. Pharmacol. 2022, 203, 115184.
“Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity“
43) E. Joffré, X. Xiao, M.S.P. Correia, I. Nookaew, S. Sasse, D. Globisch, B. Zhu, Å. Sjöling
Microbiol. Spectr. 2022, 10, e01755-21.
“Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors“
42) T. Vallianatou, N.B. Béchet, M.S.P. Correia, I. Lundgaard, D. Globisch
Metabolites 2022, 12, 21.
“Regional brain analysis of modified amino acids and dipeptides during the sleep/wake cycle“
G) D. Globisch
Research Features 2021
“Analysing gut microbiome metabolites to detect disease“
41) W. Lin, Z. Yang, A. Kaur, A. Block, M. Vujasinovic, J.-M. Löhr, D. Globisch
RSC Chem. Biol. 2021, 2, 1479-1483.
“Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines“
Highlighted in the ‘Analytical methods in Chemical Biology’ section
40) W. Lin, L.P. Conway, M. Vujasinovic, J.-M. Löhr, D. Globisch
Angew. Chem. Int. Ed. 2021, 60, 23232-23240.
“Chemoselective and highly sensitive quantification of gut microbiome and human metabolites“
39) T. Vallianatou, W. Lin, N.B. Béchet, M.S.P. Correia, N.C. Shanbhag, I. Lundgaard, D. Globisch
J. Cereb. Blood Flow Metab. 2021, 41, 12.
“Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep“
38) S. Kundu, M.A. Ali, N. Handin, L.P. Conway, V. Rendo, P. Artursson, L. He, D. Globisch, T. Sjöblom
J. Exp. Clin. Cancer Res. 2021, 40, 225.
“Common and Mutation Specific Phenotypes of KRAS and BRAF Mutations in Colorectal Cancer Cells Revealed by Integrative-Omics Analysis“
37) A. Jain, M.S.P. Correia, H. Meistermann, M. Vujasinovic, J.-M. Löhr, D. Globisch
J. Pharm. Biomed. Anal. 2021, 195, 113818. Invited for the Special Issue: “Microbiota: An analytical perspective“.
“Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites“
36) M.S.P. Correia, W. Lin, A. J. Aria, A. Jain, D. Globisch
Metabolites 2020, 10, 415.
“Rapid preparation of a large sulfated metabolite library for structure validation in human samples“
35) M.S.P. Correia+, A. Jain+, W. Alotaibi, P. Young Tie Yang, A. Rodriguez-Mateos,* D. Globisch
Free Radic. Biol. Med. 2020, 160, 745-754.
“Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host“
34) L. P. Conway+, V. Rendo+, M.S.P. Correia, I.A. Bergdahl, T. Sjöblom*, D. Globisch*
Angew. Chem. Int. Ed. 2020, 59, 14342-14346.
“Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2“
Highlighted in the SciLifeLab News
33) E. Marklund, B. van Oosten, G. Mao, E. Amselem, K. Kipper, A. Sabantsev, A. Emmerich, D. Globisch, X. Zhen, L. C. Lehmann, O. G. Berg, M. Johansson, J. Elf, S. Deindl
Nature 2020, 583, 858-861.
“DNA surface exploration and operator bypassing during target search”
32) M. Nainytė, F. Müller, G. Ganazzoli, C.-Y. Chan, A. Crisp, D. Globisch, T. Carell
Chem. Eur. J. 2020, 26, 14856-14860.
“Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World”
31) W. Lin, L. P. Conway, A. Block, G. Sommi, M. Vujasinovic, J.-M. Löhr, D. Globisch
Analyst 2020, 145, 3822-3831. Featured in the Analyst Emerging Investigators Series.
Cover Art
“Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification”
F) D. Globisch
EU Research 2020.
“Intestinal microbiota metabolism – biomarker discovery for pancreatic cancer”
30) L. P. Conway, N. Garg, W. Lin, M. Vujasinovic, J.-M. Löhr, D. Globisch
Chem. Comm. 2019, 55, 9080-9083.
Cover Art
“Chemoselective Probe for Detailed Analysis of Ketones and Aldehydes Produced by Gut Microbiota in Human Samples”
29) M. S. P. Correia, M. Rao, C. Ballet, D. Globisch
ChemBioChem 2019, 20, 1678-1683. Featured in the ChemBioTalents Issue.
“Enzymatic and mass spectrometric analysis for selective identification of glucuronidated metabolites in human samples”
E) L. P. Conway, M. S. P. Correia, D. Globisch
GIT Laboratory Journal 2019.
“Hunting Gut Microbiota Metabolites – Elucidating the Metabolic Interplay with Their Human Host”
28) M. S. P. Correia⁺, C. Ballet⁺, H. Meistermann, L. P. Conway, D. Globisch
Bioorg. Med. Chem. 2019, 27, 955-962.
“Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry”
27) N. Garg⁺, L. P. Conway⁺, C. Ballet, M. S. P. Correia, F. K. S. Olsson, M. Vujasinovic, J.-M. Löhr, D. Globisch
Angew. Chem. Int. Ed. 2018, 57, 13805-13809.
“Chemoselective Probe Harboring a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism”
Highlighted in the SciLifeLab News
26) C. Ballet⁺, M. S. P. Correia⁺, L. P. Conway, T. L. Locher, L. C. Lehmann, N. Garg, M. Vujasinovic, S. Deindl, J.-M. Löhr, D. Globisch
Chem. Sci. 2018, 9, 6233-6239.
“New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites”
Featured in the 2018 Chemical Science HOT Article Collection
Highlighted in the SciLifeLab News and in a Chemical Science blog
25) N. Garg, A. Hansson, H. K. Knych, S. D. Stanley, M. Thevis, U. Bondesson, M. Hedeland, D. Globisch
Org. Biomol. Chem. 2018, 16, 698-702.
“Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control”
The Scripps Research Institute, La Jolla, CA, USA 
24) R. J. Shirey, D. Globisch, L. M. Eubanks, M. S. Hixon, K. D. Janda
ACS Infect. Dis. 2018, 4, 1423-1431.
Cover Art
“Non-Invasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis”
23) D. Globisch*, L. M. Eubanks, R. J. Shirey, K. M. Pfarr, S. Wanji, A. Y. Debrah, A. Hoerauf, K. D. Janda
Bioorg. Med. Chem. Lett. 2017, 27, 3436-3440.
“Validation of Onchocerciasis Biomarker N-Acetyltyramine-O-glucuronide (NATOG)”
22) K. Tsuchikama, M. Gooyit, T. L. Harris, J. Zhu, D. Globisch, G. F. Kaufmann, K. D. Janda
Angew. Chem. Int. Ed. 2016, 55, 4002-4006.
“Glycation Reactivity of a Quorum-Sensing Signaling Molecule”
21) D. Globisch, S. Specht, K. M. Pfarr, Lisa M. Eubanks, A. Hoerauf, K. D. Janda
Bioorg. Med. Chem. Lett. 2015, 25, 5804-5807.
“Litomosoides sigmodontis: A Jird Urine Metabolome Study”
20) X. Cai, D. Globisch, P. Thompson, J. Lin, D. Toader, N. Dimasi, C. Gao, K. D. Janda
Tetrahedron Lett. 2015, 56, 3172-3175.
“A chemoenzymatic approach toward the preparation of site-specific antibody–drug conjugates”
19) J. W. Lockner, L. Eubanks, J. M. Lively, J. Choi, J. E. Schlosburg, K. C. Collins, D. Globisch, R. J. Rosenfeld-Gunn, I. A. Wilson, K. D. Janda
Mol. Pharmacol. 2015, 12, 653-662.
“Flagellin Protein as Carrier and Adjuvant in a Cocaine Vaccine”
18) J. Zhu, M. S. Hixon, D. Globisch, G. F. Kaufmann, K. D. Janda
J. Am. Chem. Soc. 2013, 135, 7827-7830.
“Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation”
17) D. Globisch, A. Y. Moreno, M. S. Hixon, A. A. K. Nunes, J. R. Denery, S. Specht, A. Hoerauf, K. D. Janda
Proc. Natl. Acad. Sci. U S A. 2013, 110, 4218-4223.
Cover Art
“Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness”
Selected as Cover Image: Proc. Natl. Acad. Sci. U S A. 2013, 110 (11).
Research Highlight in Nature 2013, 495, 8; News of the Week in Chem. & Eng. News 2013, 91, 11; Science Now in Science February 2013.
16) D. Globisch, C. A. Lowery, K. C. McCague, K. D. Janda
Angew. Chem. Int. Ed. 2012, 51, 4204-4208.
Cover Art
“Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species”
Selected as Inside Back Cover: Angew. Chem. Int. Ed. 2012, 51, 4239.
Very Important Paper; Spotlight in ACS Chem. Biol. 2012, 7, 789-790; Highlight in Angew. Chem. Int. Ed. 2012, 51, 6314-6315.
15) J. S. Zakhari, I. Kinoyama, M. S. Hixon, A. Di Mola, D. Globisch, K. D. Janda
Bioorg. Med. Chem. 2011, 19, 6203-6209.
“Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4‑diaminopyridine prodrug design and characterization”
Ludwig-Maximilians-University München, Munich, Germany 
14) C. Brandmayr, M. Wagner, T. Brückl, D. Globisch, D. Pearson, A. C. Kneuttinger, V. Reiter, A. Hienzsch, S. Koch, I. Thoma, P. Thumbs, S. Michalakis, M. Müller, M. Biel, T. Carell
Angew. Chem. Int. Ed. 2012, 51, 11162-11165.
“Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency”
13) T. F. Kraus+, D. Globisch+, M. Wagner, S. Eigenbrod, D. Widmann, M. Münzel, M. Müller, T. Pfaffeneder, B. Hackner, W. Feiden, U. Schüller, T. Carell, H. A. Kretzschmar
Int. J. Cancer 2012, 131, 1577-1590.
“Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base”, are associated with anaplasia in human brain tumors”
+: These authors contributed equally
12) V. Reiter, D. Matschkal, M. Wagner, D. Globisch, A. Kneuttinger, M. Müller, T. Carell
Nucleic Acids Res. 2012, 40, 6235-6240.
“The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA”
11) D. Globisch, D. Pearson, A. Hienzsch, T. Brückl, M. Wagner, I. Thoma, P. Thumbs, V. Reiter, A. C. Kneuttinger, M. Müller, S. A. Sieber, T. Carell
Angew. Chem. Int. Ed. 2011, 50, 9739-9742.
“Systems-Based Analysis of Modified tRNA Bases” Selected as Hot Paper.
10) M. Münzel+, D. Globisch+, T. Carell
Angew. Chem. Int. Ed. 2011, 50, 6460-6468; Angew. Chem. 2011, 123, 6588-6596.
“5-Hydroxymethylcytosine, the Sixth Base of the Genome” (Minireview)
9) M. Münzel, C. Szeibert, A. F. Glas, D. Globisch, T. Carell
J. Am. Chem. Soc. 2011, 133, 5186-5189.
“Discovery and Synthesis of a new UV-induced Intrastrand C(4-8)G Photolesion”
8) D. Pearson, A. Hienzsch, M. Wagner, D. Globisch, V. Reiter, D. Özden, T. Carell
Chem. Comm. 2011, 47, 5196-5198.
“LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA”
7) D. Globisch+, M. Münzel+, M. Müller, S. Michalakis, M. Wagner, S. Koch, T. Brückl, M. Biel, T. Carell
PLoS One 2010, 5, e15367.
>786 citations (Aug 2024, Web of Knowledge)
“Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates”
6) M. Münzel, D. Globisch, C. Trindler, T. Carell
Org. Lett. 2010, 12, 5671-5673.
“Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA”
5) M. Münzel+, D. Globisch+, T. Brückl, M. Wagner, V. Welzmiller, S. Michalakis, M. Müller, M. Biel, T. Carell
Angew. Chem. Int. Ed. 2010, 49, 5375-5377.
“Quantification of the sixth DNA base hydroxymethylcytosine in the brain”
Highlight in Chem. Eng. News 2010, 88 (No 27), 24; Selected as Hot Paper.
4) T. Brückl+, D. Globisch+, M. Wagner, M. Müller, T. Carell
Angew. Chem. Int. Ed. 2009, 48, 7932-7934.
“Parallel Isotope-Based Quantification of Modified tRNA Nucleosides”
Highlight in Chem. Eng. News 2009, 87 (No 38), 35; Selected as Hot Paper.
University of Southern Denmark, Odense, Denmark 
3) Y. M. Loksha, D. Globisch, R. Loddo, G. Collu, P. La Colla, E. B. Pedersen
ChemMedChem 2010, 5, 1847-1849.
“A Novel Synthetic Route for the Anti-HIV Drug MC-1220 and its Analogues”
2) D. Globisch, N. Bomholt, V. V. Filichev, E. B. Pedersen
Helv. Chim. Acta 2008, 91, 805-818.
“Stability of Hoogsteen Type triplexes – Electrostatic attraction between duplex backbone and TFO using an intercalating conjugate”
1) Y. M. Loksha, D. Globisch, E. B. Pedersen, P. La Colla, G. Collu, R. Loddo
J. Heterocycl. Chem. 2008, 45, 1161-1166.
“Synthesis and Anti-HIV-1 Evaluation of 1,5-Disubstituted Pyrimidine-2,4-diones”
+: These authors contributed equally
*: Shared corresponding authorships
Conference Articles
D) N. Rameika, X. Zhang, V. Rendo, S. Kundu, D. Globisch, M.S.P. Correia, I. Stoimenov, T. Sjöblom
Ann. Oncol. 2022, 33, 4, Page S303.
“P-150 Targeting loss of heterozygosity in colorectal cancer”
C) G.M. Ferri, C.M. Harvey, D. Globisch, K.D. Janda, K.N. Allen
FASEB J. 2018, 32:674.16.
“Using M. marinum T6PP as a Model for M. tuberculosis Inhibitor Design”
B) C. Harvey, C. Liu, D. Globisch, K.D. Janda, D. Dunaway-Mariano, K. Allen
FASEB J. 2017, 31:923.5.
“Trehalose-6-Phosphate Phosphatase Structure and Inhibitor Design”
A) E. B. Pedersen, A.M.A. Osman, D. Globisch, M. Paramasiva, S. Cogoi, N. Bomholt, P.T. Jørgensen, L.E. Xodo, V.V. Filichev
Nucleic Acids Symp Ser (Oxf) 2008, 52, 37-38.
“Triplex glue by synthesizing conjugated flexible intercalators”